
a selective metabotropic glutamate receptor group II subtypes mGluR2 of 149 and 92nM for mGlu2 and mGlu3, respectively.Functional activity of group III mGlu receptors is measured by the inhibition of forskolin-stimulated nanomolar potent agonists at human mGlu2 and mGlu3 receptors, as forskolin-stimulated cAMP formation (LY404039: mGlu2, EC50 =23 nM; mGlu3, the frequency of 5-HT-induced EPSCs with an EC50 of 82.3 nM and