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Signal Inhibitors and Activators
Rapamycin
$60/ 0.1mg
QuantityTotal: $60
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Product Information
Molecular Weight 914.2
Purity 98% (TLC: 10% MeOH/Methylene chloride; Rf = 0.51)
Recommended Dilutions Binds to and inhibits the FK506 binding protein (FKBP) proline rotamase. Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 to S phase. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase.
Storage/Stability Store solutions at -20°C for up to 1 year.
References1. J.Y.Chang et al. Trends Pharmacol.Sci. 1991 12 218
2. J.Choi et al. Science 1996 273 183
3. D.M.Sabatini et al. J.Biol.Chem. 1995 270 20875
4. E.J.Brown et al. Nature 1995 377 441
5. J.E.Kay et al. Immunology 1991 72 544
6. W.G.Morice et al. J.Biol.Chem. 1993 268 3734
7. J.Heitman et al. Science 1991 253 905
8. D.J.Price et al. Science 1992 257 973
9. D.C.Fingar et al. J.Biol.Chem. 1993 268 3005
10. J.Chung et al. Cell 1992 69 1227
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
2. J.Choi et al. Science 1996 273 183
3. D.M.Sabatini et al. J.Biol.Chem. 1995 270 20875
4. E.J.Brown et al. Nature 1995 377 441
5. J.E.Kay et al. Immunology 1991 72 544
6. W.G.Morice et al. J.Biol.Chem. 1993 268 3734
7. J.Heitman et al. Science 1991 253 905
8. D.J.Price et al. Science 1992 257 973
9. D.C.Fingar et al. J.Biol.Chem. 1993 268 3005
10. J.Chung et al. Cell 1992 69 1227
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price60$
Form Or Antibody
Form of Antibody RapamycinCAS NO: 53123-88-9
PHYSICAL APPEARANCE: Off-white or yellow solid MOLECULAR FORMULA: C51H79NO13 MOLECULAR WEIGHT: 914.2 PURITY: 98% (TLC: 10% MeOH/Methylene chloride; Rf = STORAGE: Store solutions at -20°C for up to 1 year. APPLICATION NOTES: Binds to and inhibits the FK506 Rapamycin is bound simultaneously by FKBP12 and FRAP
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