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Signal Inhibitors and Activators
BAY 11-7082NF-κB Inhibitor
$60/
QuantityTotal: $60
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Form Or Antibody
Form of Antibody BAY 11-7082(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
CAS NO: 195462-67-7
CAS NO: 195462-67-7
Product Information
Molecular Weight 207.3
Purity 99%
Recommended Dilutions Inhibitor of cytokine-induced NF-κB phosphorylation. Inhibited NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8, in TNF treated HUVECs, with IC50’s of 5-10 μM. The inhibition of NF-κB phosphorylation and cell adhesion molecule expression and the stabilization of NF-κB were found to be irreversible effects.
Storage/Stability Store solutions at -20°C for up to 1 year.
ReferencesJ.W. Pierce et al. J. Biol. Chem. 1997 272 21096
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price60$
PHYSICAL APPEARANCE: Off-white solid (m.p. 128-130°C) MOLECULAR FORMULA: C10H9NO2S MOLECULAR WEIGHT: 207.3 PURITY: 99% STORAGE: Store solutions at -20°C for up to 1 year. APPLICATION NOTES: Inhibitor of cytokine-induced NF-κB expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8, in TNF
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