
FTY720(Fingolimod) is a potent sphingosine-1-phosphate (S1P) receptors agonist with nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of is a novel immunomodulating agent and can sequester lymphocytes in lymph them from moving to the central nervous system for auto-immune responses in and was originally proposed as a anti-rejection medication indicated post-transplantation. phosphorylated by sphingosine kinase and prevents disease in a mouse model of