
oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention of thromboembolic disorders. Rivaroxaban inhibits clot-associated,free FXa activity, in addition, it reduces thrombin generation. activated serine protease Factor Xa (FXa) plays a central role in the blood coagulation the conversion of prothrombin to thrombin through the prothrombinase complex, FXa, FVa, prothrombin, and Ca2+ on a phospholipid surface. Thrombin has