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Signal Inhibitors and Activators
PF-3845
$362.4/ 10mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $362
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Product Information
Kinase Inhibitor Name YO-01027
M.W. 463.48 Formula: C26H23F2N3O3 Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No.: 209984-56-5
Price362.4$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the and Notch, respectively. YO-01027 is used as an anti-Alzheimer agent. YO-01027 the gamma-secretase complex. Unlike other gamma-secretase inhibitors,YO-01027 functional domain of the complex. YO-01027 targets the N-terminal Presenilin fragment gamma-secretase inhibitor Compound E (Cpn E), whereas DFK167 and DAPT, another inhibitors, bind to the catalytic site of the Presenilin aspartyl protease subunit
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