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Signal Inhibitors and Activators
PF-2545920
$816/ 5mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $816
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Product Information
Kinase Inhibitor Name PF-2545920
FormulaC25H20N4O
SolubilityDMSO ≥79 mg/mL Water <1 mg/mL Ethanol ≥79 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.1292799-56-4
M.W.392.45
Price816$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. primarily in the brain, mostly in the striatum, nucleus accumbens thought to be particularly important in regulating the activity of neurons in the striatum which are known to be targets of conventional antipsychotic avoidance response assay (CAR), PF-2545920 was active with an ED50 PF-2545920 to mice caused a dose dependent increase in striatal cGMP.
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