
hydrochloride is a potent cyclin-dependent kinases inhibitor with an is the first cyclin-dependent kinase inhibitor. At the nanomolar prevented rhabdoid cell growth with an IC50 ranging from hydrochloride induced G1 and G2 arrest and apoptosis manner. These influences were associated with the down- p21, and induction of caspase 3/7 activities. At a dose of 7.5