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Signal Inhibitors and Activators
D-106669
$816/ 5mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $816
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Product Information
Kinase Inhibitor Name D-106669
FormulaC17H18N6O
SolubilityStability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.938444-93-0
M.W.322.36
Price816$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
is a highly selective PI3K inhibitor with a submicromolar inhibition. It is well that the pyridopyrazine core of D-106669 is substituted by an aniline residue, base scaffold of a more advanced derivative AEZS-126 which is also identified as a inhibitor with an IC50 of < 10nM for PI3K alpha. When was given at oral dose of D-106669 presented certain inhibitory activity in A549 xenografts mouse model. optimized compound of NVP-BEZ235 is NVP-BEZ235 that is also a PI3K alpha
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