
a potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with human and mouse DGAT-1, respectively. acyltransferases (DGAT) exert their action in the final reaction step in the was reported that DGAT-1 contributed to the development of diet-induced obesity A 922500 has less inhibitory activity against DGAT-2, phylogenetic family A cholesterol acyltransferase-1 and -2 than DGAT-1. A 922500 inhibited