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Signal Inhibitors and Activators
A-674563
$513.6/ 2mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $514
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Product Information
Kinase Inhibitor Name A-674563
FormulaC22H22N4O
SolubilityDMSO ≥72 mg/mL Water ≥72 mg/mL Ethanol ≥12 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.552325-73-2
M.W.358.44
Price513.5999999999999$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. While observed in vivo, A-674563 indicated significantly effects on depolarization of assay and severe CV toxicity (e.g. hypotension) in vivo. An X-ray structure of kinase A, which has 80% homology with Akt in the kinase domain, suggested bound in the ligand-protein complex. The Akt inhibitor A-674563 displayed
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