
potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It is well target of rapamycin (mTOR) is centrally involved in cell growth, Significantly, the pyrazolopyrimidines were selective for mTOR over PI3Kα were poorly active in a panel of 24 protein kinases. Unlike the mTORC2-dependent phosphorylation of AKT in vitro and in vivo. In various the mTORC1 substrate P-S6K(T389) and mTORC2 substrate