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Signal Inhibitors and Activators
S/GSK1349572 (GSK1349572)
$816/ 5mg
QuantityTotal: $816
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Product Information
Kinase Inhibitor Name S/GSK1349572 (GSK1349572)
FormulaC20H19F2N3O5
SolubilityDMSO ≥61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.1051375-16-6
Biological ActivityS/GSK1349572 (GSK 1349572) is a novel potent integrase inhibitor with an IC50 of 2.7 nM in vitro. S/GSK1349572 (GSK 1349572) is a compound for the treatment of HIV infection. S/GSK1349572 (GSK 1349572) exhibited in vitro activity against most clinical isolates obtained from patients failing RAL-based therapy. In PBMC cell assay, S/GSK1349572 inhibited HIV integrase with the antiviral IC50=0.51 and IC90=2.0 nM. In MT-4 antiviral assays, potency shift extrapolated to 100% human serum was 75-fold providing PA-IC90=152 nM in PBMCs. S/GSK1349572 (GSK 1349572) had a markedly different resistance profile as evidenced by limited cross-resistance to RAL-resistant molecular clones, by its in vitro activity against clinical isolates obtained from patients failing RAL-based therapy, and in selecting different mutations with low level FC during serial passage. In vitro experiments support the potential for S/GSK1349572 (GSK 1349572) to have a higher genetic barrier to resistance when compared to 1st generation integrase inhibitors. [1][2]
M.W.419.38
ReferencesThe pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price816$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
(GSK 1349572) is a novel potent integrase inhibitor with an IC50 of 2.7 (GSK 1349572) is a compound for the treatment of HIV infection. S/GSK1349572 in vitro activity against most clinical isolates obtained from patients failing cell assay, S/GSK1349572 inhibited HIV integrase with the antiviral In MT-4 antiviral assays, potency shift extrapolated to 100% human serum PA-IC90=152 nM in PBMCs. S/GSK1349572 (GSK 1349572) had a markedly
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