PF-04929113

(SNX-5422) is a potent and selective Hsp90 inhibitor with an IC50 of median chaperone that plays a key role in the conformational maturation such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as that are important in cell cycle regulation or immune responses. synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) activity. Although the mechanism of action remains to be fully elucidated,