
synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 90 (Hsp90) chaperone not only regulates the conformational of oncogenic kinases as well as transcription factors. compounds SNX-5542. SNX-2112 is rapidly transformed form of tumor cell lines, SNX-2112 degraded HER2 and mutant inhibited extracellular signal-modulated kinase and Akt activation.SNX-2112