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Signal Inhibitors and Activators
DCC-2036
$1118.4/ 10mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $1118
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Product Information
Kinase Inhibitor Name DCC-2036
FormulaC30H28FN7O3
SolubilityDMSO ≥111 mg/mL Water <1 mg/mL Ethanol ≥16 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.1020172-07-9
M.W.553.59
Price1118.4$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
an ABL switch control inhibitor with IC50 of 0.8 and 2 nM for respectively. DCC-2036 strongly prevents both unphosphorylated and a type II inactive conformation, and retains efficacy against the majority mutants, including T315I. DCC-2036 suppresses BCR-ABL1(T315I)-expressing survival in mouse models of T315I mutant CML and B-lymphoblastic patient leukemia cells expressing T315I in vitro and in vivo, supporting
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