
a potent and selective positive allosteric α7 neuronal nicotinic with an EC50 of 0.2 μM. PNU-120596 has no detectable effect on Discovered in a high-throughput screen, PNU-120596 enhanced by an engineered variant of the human α7 nAChR. Electrophysiology PNU-120596 increased peak agonist-evoked currents mediated proved a pronounced prolongation of the triggered response in