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Signal Inhibitors and Activators
LY2603618 (IC-83)
$633.6/ 5mg
QuantityTotal: $634
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Product Information
Kinase Inhibitor Name LY2603618 (IC-83)
FormulaC18H22BrN5O3
SolubilityDMSO ≥21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.911222-45-2
Biological ActivityLY2603618 (IC-83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY2603618 (IC-83) binds to and inhibits the activity of chk1, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk1, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk1 is overexpressed by a variety of cancer cell types. [1][2]
M.W.436.3
ReferencesNew insights into checkpoint kinase 1 in the DNA damage response signaling network. Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83.
http://www.springer.com/biomed/cancer/book/978-1-60761-177-6
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
http://www.springer.com/biomed/cancer/book/978-1-60761-177-6
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price633.5999999999999$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
is a highly selective Chk 1 inhibitor with potential antitumor inhibits the activity of chk1, which may prevent the repair of thus potentiating the antitumor efficacies of various serine-threonine kinase, is a key component in the DNA is activated by double-stranded breaks (DSBs); activated chk1
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