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Signal Inhibitors and Activators
Omecamtiv mecarbil (CK-1827452)
$633.6/ 5mg
QuantityTotal: $634
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Product Information
Kinase Inhibitor Name Omecamtiv mecarbil (CK-1827452)
FormulaC20H24FN5O3
SolubilityDMSO ≥80 mg/mL Water <1 mg/mL Ethanol ≥14 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.873697-71-3
Biological ActivityOmecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 μM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, enhance Ca2+ fluxes and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) accelerates productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency. [1][2]
M.W.401.43
ReferencesCK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. Solaro RJ et al. IDrugs. 2009 Apr;12(4):243-51.
http://en.wikipedia.org/wiki/Omecamtiv_Mecarbil_(CK-1827452)
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
http://en.wikipedia.org/wiki/Omecamtiv_Mecarbil_(CK-1827452)
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price633.5999999999999$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator 0.6 μM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves increasing the systolic ejection duration/stroke volume, without consuming more ATP
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