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Signal Inhibitors and Activators
LDN193189
$331.2/ 2mg1 PHYSICAL AND CHEMICAL PROPERTIES
QuantityTotal: $331
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Product Information
Kinase Inhibitor Name LDN193189
FormulaC25H22N6
SolubilityDMSO ≥4 mg/mL Water ≥30 mg/mL Ethanol <1 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.1062368-24-4
M.W.406.48
Price331.2$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM LDN193189 also inhibits BMP type I receptors ALK6 (TGFβ1/BMP phosphorylation. LDN193189 inhibits FOP and ectopic ossification and treatment of NSCLC lung tumors. LDN193189 affects not only the Smad pathways induced by either BMP2, BMP6 or GDF5. The activation of cells was inhibited by LDN193189.
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