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Signal Inhibitors and Activators
Mitoxantrone
$151.2/ 50mg
QuantityTotal: $151
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Product Information
Kinase Inhibitor Name Mitoxantrone Hydrochloride
FormulaC22H30Cl2N4O6
SolubilityStability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.70476-82-3
Biological ActivityMitoxantrone Hydrochloride (NSC301739; Immunex) is a hydrochloride salt of mitoxantrone which is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM).Mitoxantrone Hydrochloride (NSC301739; Immunex) is also a synthetic antineoplastic anthracenedione. Mitoxantrone Hydrochloride (NSC301739; Immunex) is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone Hydrochloride (NSC301739; Immunex) also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. Mitoxantrone Hydrochloride (NSC301739; Immunex) has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
M.W.517.4
ReferencesThe pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price151.2$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
Mitoxantrone Hydrochloride (NSC301739; Immunex) is a hydrochloride salt of mitoxantrone antineoplastic anthracenedione (IC50 = 0.42 mM).Mitoxantrone Hydrochloride (NSC301739; is also a synthetic antineoplastic anthracenedione. Mitoxantrone Hydrochloride (NSC301739; is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through causes crosslinks and strand breaks. Mitoxantrone Hydrochloride (NSC301739; Immunex) with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an
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