World supplier of antibodies, antigens and kits since 2007
Signal Inhibitors and Activators
Manidipine dihydrochloride (CV-4093)
$151.5/ 25mg
QuantityTotal: $152
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Kinase Inhibitor Name Manidipine dihydrochloride (CV-4093)
FormulaC35H38N4O6.2HCl
SolubilityDMSO ≥11 mg/mL Water <1 mg/mL Ethanol <1 mg/mLStability:2 years -20℃ Powder1 week -4℃ in DMSO1 month -80℃ in DMSO
CAS No.89226-75-5
Biological ActivityManidipine dihydrochloride (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. Manidipine dihydrochloride (CV-4093) causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine dihydrochloride (CV-4093) is used clinically as an antihypertensive. [1][2][3] Manidipine dihydrochloride (CV-4093) suppressed the DNA synthesis of vascular smooth muscle cells (VSMC) dose dependently at concentrations of more than 10 nM. Mandipine hydrochloride (1 µM) suppressed proliferation of VSMC to 50% of the control value. Manidipine hydrochloride stimulated the synthesis of GAG at concentrations above 0.01 nM. Manidipine hydrochloride (10 nM) stimulated synthesis of glycosaminoglycans(GAG) to 450% of control. [4]
M.W.683.62
Referenceshttp://en.wikipedia.org/wiki/Manidipine http://en.wikipedia.org/wiki/Manidipine ;
Manidipine: a review of its use in hypertension. Cheer SM et al. Drugs. 2001;61(12):1777-99.
Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. Tojo A et al. J Cardiovasc Pharmacol. 1992 Dec;20(6):895-9.
Effects of manidipine hydrochloride on proliferation and glycosaminoglycan synthesis of cultured vascular smooth muscle cells. Morimoto S et al. Blood Press Suppl. 1992;3:27-9.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Manidipine: a review of its use in hypertension. Cheer SM et al. Drugs. 2001;61(12):1777-99.
Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. Tojo A et al. J Cardiovasc Pharmacol. 1992 Dec;20(6):895-9.
Effects of manidipine hydrochloride on proliferation and glycosaminoglycan synthesis of cultured vascular smooth muscle cells. Morimoto S et al. Blood Press Suppl. 1992;3:27-9.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price151.5$
![dihydrochloride (CV-4093) is a hydrochloride salt of manidipine that highly vasoselective dihydropyridine calcium antagonist with an (CV-4093) causes systemic vasodilation by inhibiting the in smooth muscle cells. Manidipine dihydrochloride (CV-4093) is [1][2][3] Manidipine dihydrochloride (CV-4093) suppressed the muscle cells (VSMC) dose dependently at concentrations of more](/img/pdfimg/E1KS2482/E1KS2482-001.jpg)
dihydrochloride (CV-4093) is a hydrochloride salt of manidipine that highly vasoselective dihydropyridine calcium antagonist with an (CV-4093) causes systemic vasodilation by inhibiting the in smooth muscle cells. Manidipine dihydrochloride (CV-4093) is [1][2][3] Manidipine dihydrochloride (CV-4093) suppressed the muscle cells (VSMC) dose dependently at concentrations of more
Categories by research area
Categories by product type
- Antibodies
- Primary Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- ELISA Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits
- Overexpression Cell Lines
- Cell Lysates
- Purification Resins
- 2019-nCoV & Monkeypox