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Signal Inhibitors and Activators
Imatinib (Gleevec)
$211.2/ 250mg
QuantityTotal: $211
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Product Information
Kinase Inhibitor Name Imatinib (Gleevec)
FormulaC29H31N7O
SolubilityDMSO ≥5 mg/mL Water <1 mg/mL Ethanol ≥3 mg/mL
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
Stability:
2 years -20℃ Powder
1 week -4℃ in DMSO
1 month -80℃ in DMSO
CAS No.152459-95-
Biological ActivityImatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. It act by specifically inhibiting a certain enzyme that is characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing all rapidly dividing cells, and served as a model for other targeted therapy modalities through tyrosine kinase inhibition. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl. As this is now a constitutively active tyrosine kinase, it is used to decrease bcr-abl activity. It is being used as an experimental agent to suppress platelet-derived growth factor (PDGF) by inhibiting its receptor (PDGF-Rβ).
M.W.493.6
ReferencesThe pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price211.2$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
is a number of tyrosine kinase enzymes specific inhibitor. It act enzyme that is characteristic of a particular cancer cell, rather than all rapidly dividing cells, and served as a model for other targeted therapy kinase inhibition. In chronic myelogenous leukemia, the Philadelphia of abl with bcr (breakpoint cluster region), termed bcr-abl. As tyrosine kinase, it is used to decrease bcr-abl activity. It is being
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