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Signal Inhibitors and Activators
LY-294002PI3K Inhibitor
$55/
QuantityTotal: $55
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Product Information
Molecular Weight 307.4
Purity 99% (TLC)
Solubility Soluble in DMSO (25 mg/ml warm) and ethanol (25 mg/ml warm)
Recommended Dilutions Potent, cell permeable and specific inhibitor of phosphatidylinositol 3- kinase (IC50 = 1.4 μM; purified PI 3-kinase). Does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 μM. In intact neutrophils stimulated with fMet-Leu-Phe, LY 294002 completely abolished PI 3-kinase activity at 50 μM without cell toxicity. Also blocked proliferation of cultured rabbit aortic smooth muscle cells without cell death. Induces apoptosis.
Storage/Stability Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
References1 C.J.Vlahos et al. J.Biol.Chem. 1994 269 5241
2 V.Sanchez Margalet et al. Biochem.Biophys.Res.Commun. 1994 204 446
3 T.J.Kovacsovics et al. J.Biol.Chem. 1995 270 11358
4 R.Yao and G.M.Cooper Science 1995 267 2003
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
2 V.Sanchez Margalet et al. Biochem.Biophys.Res.Commun. 1994 204 446
3 T.J.Kovacsovics et al. J.Biol.Chem. 1995 270 11358
4 R.Yao and G.M.Cooper Science 1995 267 2003
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price55$
PHYSICAL APPEARANCE: Off-white-pale yellow solid (m.p. MOLECULAR FORMULA: C19H17NO3 MOLECULAR WEIGHT: 307.4 PURITY: 99% (TLC) SOLUBILITY: Soluble in DMSO (25 mg/ml warm) and ethanol STORAGE: Store, as supplied, at -20°C for up to 1 year. Store
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