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PARP1 Antibody
Datasheet   

  • Catalog Number:

    E230014-1

  • Amount:

    50ul

  • Gene ID:

    NM_020367.4

  • Immunogen:

    Synthetic peptide corresponding to C-terminus amino acids of PARP1 human protein.

  • Reactivity:

    Hu

  • Recommended Dilutions:

    . ELISA: 1/5000 - 1/20000. WB: 1/5000 - 1/10000.

  • Cellular localization:

    Nucleus

  • Relevance:

    PARP (Poly (ADP-ribose) polymerase) is a 113 kDa nuclear protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein acts as a molecular “nick sensor” and functions in base excision repair, poly(ADPribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2, and during apoptosis, ICE family members, such as caspase 3 and 7, cleave PARP to yield an 85 kDa and a 25 kDa fragment.

  • Purity:

    Protein G-Sepharose affinity purified.

  • Form of Antibody:

    Liquid

  • Preservative:

    0.02% Sodium Azide and 50% glycerol, 1%BSA, PBS, pH7.4.

  • Storage/Stability:

    Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • PARP antibody (E230014) at 1/5000dilution interacts with 293T whole cell lysate 40ug/Lane. Predicted band size: 113KDa. Observed band size: 113KDa. Additional band size: 200KDa, 70KDa.

  • Price:

    145$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

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Catalog Number

  • Amount:50ul
  • Price:145$

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