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LIN28A (2C1) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200808

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of LIN28,and does not cross-react with related proteins.

  • Entrez summary:

    null

  • UniPort summary Function:

    Acts as a ´translational enhancer´, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5´-GGAG-3´ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5´-GGAG-3´ motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

  • Immunogen:

    Purified recombinant human LIN28A protein fragments expressed in E.coli

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2a

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm.Nucleus

  • Reactivity:

    Human,Mouse

  • Applications:

    WB

  • Molecular Weight:

    Calculated MW: 23 kDa; Observed MW: 26 kDa

  • UniProt Number:

    Q9H9Z2

  • Gene ID:

    79727

  • Gene symbol:

    CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

  • Altername:

    CSDD1; FLJ12457; LIN 28; Lin-28A; LIN28; LIN28A; LN28A_HUMAN; Protein lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.

  • Western blot analysis of LIN28 in NTERA and F9 lysates using LIN28A antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    Involved in the timing of developmental events and choice of stage specific cell fates. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7.

  • Clone Number:

    2C1-F9-A2

  • Gene Name:

    LIN28A

  • Recommended Dilutions:

    WB: 1/500-1/1000

  • Swiss-Prot No.:

    Q9H9Z2

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Western blot analysis of LIN28A (2C1) in LIN28B and LIN28A recombinant antigen fragments using LIN28A antibody.

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Catalog Number

  • Amount:100ul
  • Price:255$

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LIN28A (2C1) Mouse mAb | EnoGene Biotech Co. Ltd