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Hsp27 (7E5) Mouse mAb
Datasheet
Catalog Number:
E2200778Amount:
100ulSource:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of HSPB1 and does not cross-react with related proteins.Entrez summary:
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).UniPort summary Function:
Involved in stress resistance and actin organization.Immunogen:
Purified recombinant human Hsp27 protein fragments expressed in E.coli.Antibody type:
Monoclonal AntibodyIsotype:
IgG1Purification:
Affinity PurifiedCellular localization:
NucleusReactivity:
Human,MonkeyApplications:
WB,ICC/IFMolecular Weight:
Calculated MW: 23 kDa; Observed MW: 27 kDaUniProt Number:
P04792Gene ID:
3315Gene symbol:
CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067Altername:
HSPB1; HSP27; HSP28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels. In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway.Clone Number:
7E5-1F9-D9Gene Name:
HSPB1Recommended Dilutions:
WB: 1/500-1/1000 IF: 1/50-1/200Swiss-Prot No.:
P04792Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Western blot detection of HSPB1 in Hela, HsHela, A431, COS7, LNCAP&MCF7 cell lysates and using HSPB1 antibody (1:1000 diluted). Predicted band size: 23KDa Observed band size:27KDa.
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