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PGP9.5 (7B8) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200767

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of UCHL1 and does not cross-react with related proteins.

  • Entrez summary:

    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

  • UniPort summary Function:

    Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity

  • Immunogen:

    Purified recombinant human UCHL1 / PGP9.5 protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2b

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm

  • Reactivity:

    Human,Monkey

  • Applications:

    WB,ICC/IF

  • Molecular Weight:

    Calculated MW: 25 kDa; Observed MW: 25 kDa

  • UniProt Number:

    P09936

  • Gene ID:

    7345

  • Gene symbol:

    PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5

  • Altername:

    UCHL1 / PGP9.5; UCHL1; B220; CD 45; CD45; cd45 antigen; ec3.1.3.48; GP 180; GP180; Human homolog of severe combined immunodeficiency due to PTPRC deficiency; L CA; L-CA; lca; Leukocyte common antigen; LY 5; LY5; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; PTPRC; PTPRC_HUMAN; Receptor-type tyrosine-protein phosphatase C; SCID due to PTPRC deficiency; t200; T200 glycoprotein; T200 leukocyte common antigen.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    PGP9.5 is a single chain transmembraneous glycoprotein which represents the low molecular weight isoform of the Leucocyte Common Antigen (LCA). Hydrolyze isopeptide bonds between the carboxy-terminal glycine of Ub and the ε-amino group of lysine on target proteins and involved in the cotranslational processing of pro-ubiquitin and ribosomal proteins translated as ubiquitin fusions.

  • Clone Number:

    7B8-G5-B8

  • Gene Name:

    UCHL1

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200

  • Swiss-Prot No.:

    P09936

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Western blot detection of UCHL1 in U251,Raji&IMP32 cell lysates and using UCHL1 antibody (1:1000 diluted). Predicted band size: 25KDa Observed band size:25KDa.

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Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

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PGP9.5 (7B8) Mouse mAb | EnoGene Biotech Co. Ltd