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cIAP2 (1F12) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200766

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of BIRC3 and does not cross-react with related proteins.

  • Entrez summary:

    This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases.The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione,a potent inducer of free radicals.It contains 3 baculovirus IAP repeats and a ring finger domain.Transcript variants encoding the same isoform have been identified.

  • UniPort summary Function:

    Multi-functional protein which regulates not only caspases and apoptosis,but also modulates inflammatory signaling and immunity,mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions:acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1,RIPK2,RIPK3,RIPK4,CASP3,CASP7,CASP8,TRAF1,and BCL10.Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors(TLRs),Nodlike receptors (NLRs) and RIG-I like receptors (RLRs),collectively referred to as pattern recognition receptors (PRRs).Protects cells from spontaneous formation of the ripoptosome,a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

  • Immunogen:

    Purified recombinant human c-IAP2 protein fragments expressed in E.coli

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm.Nucleus

  • Reactivity:

    Human,Monkey

  • Applications:

    WB

  • Molecular Weight:

    Calculated MW: 68 kDa; Observed MW: 72 kDa

  • UniProt Number:

    Q13489

  • Gene ID:

    330

  • Gene symbol:

    AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; MALT2; RNF49; c-IAP2

  • Altername:

    cIAP2; AIP1; API2; BIRC3; CIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).

  • Clone Number:

    1F12-E5-G12

  • Gene Name:

    BIRC3

  • Recommended Dilutions:

    WB: 1/500-1/1000

  • Swiss-Prot No.:

    Q13489

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

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cIAP2 (1F12) Mouse mAb | EnoGene Biotech Co. Ltd