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FYB (2H9) Mouse mAb
Datasheet
Catalog Number:
E2200664Amount:
100ulSource:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of FYB and does not cross-react with related proteins.Entrez summary:
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.UniPort summary Function:
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.Immunogen:
Purified recombinant human FYB protein fragments expressed in E.coli.Antibody type:
Monoclonal AntibodyIsotype:
IgG1Purification:
Affinity PurifiedCellular localization:
Mitochondrion outer membrane.Reactivity:
HumanApplications:
WBMolecular Weight:
Calculated MW: 85 kDa; Observed MW: 120 kDaUniProt Number:
O15117Gene ID:
2533Gene symbol:
ADAP; PRO0823; SLAP-130Altername:
ADAP; Fyb; FYN binding protein; p120/p130; SLAP130
- Western blot analysis of FYB in 10, 15 and 20ug Jurkat lysates using FYB antibody.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.Clone Number:
2H9-H6-G10Gene Name:
FYB1Recommended Dilutions:
WB: 1/500-1/1000Swiss-Prot No.:
O15117Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Western blot detection of FYB in Jurkat, K562&TF-1 cell lysates using FYB antibody (1:1000 diluted). Predicted band size: 85kDa Observed band size: 85kDa.
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