You are here: EnoGene Home > Products > Pathological (Immunohistochemistry, IHC) antibodies > PRMT1 (4E9) Mouse mAb
PRMT1 (4E9) Mouse mAb
Datasheet
Catalog Number:
E2200639Amount:
100ulSource:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of PRMT1 and does not cross-react with related proteins.Entrez summary:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5UniPort summary Function:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 ´Arg-4´ (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.Immunogen:
Purified recombinant human PRMT1 protein fragments expressed in E.coli.Antibody type:
Monoclonal AntibodyIsotype:
IgG2bPurification:
Affinity PurifiedCellular localization:
Nucleus. CytoplasmReactivity:
HumanApplications:
WBMolecular Weight:
Calculated MW: 42 kDa; Observed MW: 42 kDaUniProt Number:
Q99873Gene ID:
3276Gene symbol:
ANM1; HCP1; IR1B4; HRMT1L2Altername:
ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; Histone-arginine N-methyltransferase PRMT1; HMT 2; HMT1 (hnRNP methyltransferase; HMT1 (hnRNP methyltransferase S. cerevisiae) like 2; HMT1 hnRNP methyltransferase; HMT1 hnRNP methyltransferase like 2 (S. cerevisiae); HMT1 hnRNP methyltransferase like 2; HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae); HMT2; HRMT1 L2; HRMT1L 2; HRMT1L2; Human mRNA for suppressor for yeast mutant; Human mRNA for suppressor for yeast mutant complete cds; Interferon receptor 1 bound protein 4; Interferon receptor 1 bound protein4; Interferon receptor 1-bound protein 4; Interferon receptor 1bound protein 4; IR1 B4; IR1B 4; IR1B4; Mrmt 1; Mrmt1; PRMT 1; PRMT1; Protein arginine methyltransferase 1; Protein arginine N methyltransferase 1; Protein arginine N methyltransferase1; Protein arginine N-methyltransferase 1; R1B4; S. cerevisiae like 2.
- Western blot analysis of PRMT1 in Hela, A549 and SW480 lysates using PRMT1 antibody.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation.Clone Number:
4E9-H9-H12Gene Name:
PRMT1Recommended Dilutions:
WB: 1/500-1/1000Swiss-Prot No.:
Q99873Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Related Products
- c-Jun (Phospho-Ser63) Antibody Datasheet COA
Catalog Number:
E011001-1Amount:
50μg/50μlReactivity:
Human, MouseApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P05412Price:
145$
- c-Jun (Phospho-Ser63) Antibody Datasheet
Catalog Number:
E011001-2Amount:
100μg/100μlReactivity:
Human, MouseApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P05412Price:
225$
- Rb Polyclonal Antibody Datasheet
Catalog Number:
E90003Amount:
100ulReactivity:
H MApplications:
WB IHCSwiss-Prot No.:
P06400Price:
225$
- Elk-1 (Phospho-Ser383) Antibody Datasheet
Catalog Number:
E011004-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P19419Price:
145$
- Elk-1 (Phospho-Ser383) Antibody Datasheet
Catalog Number:
E011004-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P19419Price:
225$
Catalog Number
- Amount:100ul
- Price:255$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits