You are here: EnoGene Home > Products > Pathological (Immunohistochemistry, IHC) antibodies > NUP98 (3B8) Mouse mAb

NUP98 (3B8) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200637

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of NUP98 and does not cross-react with related proteins.

  • Entrez summary:

    Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

  • UniPort summary Function:

    Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.

  • Immunogen:

    Purified recombinant human NUP98 protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Nucleus ? nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.

  • Reactivity:

    Human

  • Applications:

    WB,IP

  • Molecular Weight:

    Calculated MW: 198 kDa; Observed MW: 98 kDa

  • UniProt Number:

    P52948

  • Gene ID:

    4928

  • Gene symbol:

    ADIR2; NUP96; NUP196

  • Altername:

    96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.

  • Western blot analysis of NUP98 in Hela, Jurkat and MCF-7 lysates using NUP98 antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.

  • Clone Number:

    3B8-D7-H10

  • Gene Name:

    NUP98

  • Recommended Dilutions:

    WB: 1/500-1/1000 IP: 1/20

  • Swiss-Prot No.:

    P52948

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Immunoprecipitation analysis of Hela cell lysates using NUP98 antibody.

Add to Cart

Related Products

c-Jun (Phospho-Ser63) Antibody
c-Jun (Phospho-Ser63) Antibody Datasheet  COA   

  • Catalog Number:

    E011001-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse

  • Applications:

    WB: 1:500~1:1000 IHC: 1:50~1:100

  • Swiss-Prot No.:

    P05412

  • Price:

    145$
  • Add to Cart
c-Jun (Phospho-Ser63) Antibody
c-Jun (Phospho-Ser63) Antibody Datasheet  

  • Catalog Number:

    E011001-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse

  • Applications:

    WB: 1:500~1:1000 IHC: 1:50~1:100

  • Swiss-Prot No.:

    P05412

  • Price:

    225$
  • Add to Cart
Rb Polyclonal Antibody
Rb Polyclonal Antibody Datasheet  

  • Catalog Number:

    E90003

  • Amount:

    100ul

  • Reactivity:

    H M

  • Applications:

    WB IHC

  • Swiss-Prot No.:

    P06400

  • Price:

    225$
  • Add to Cart
Elk-1 (Phospho-Ser383) Antibody
Elk-1 (Phospho-Ser383) Antibody Datasheet  

  • Catalog Number:

    E011004-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IHC: 1:50~1:100

  • Swiss-Prot No.:

    P19419

  • Price:

    145$
  • Add to Cart
Elk-1 (Phospho-Ser383) Antibody
Elk-1 (Phospho-Ser383) Antibody Datasheet  

  • Catalog Number:

    E011004-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IHC: 1:50~1:100

  • Swiss-Prot No.:

    P19419

  • Price:

    225$
  • Add to Cart

Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

AbPromise

Contact us

NUP98 (3B8) Mouse mAb | EnoGene Biotech Co. Ltd