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CKMT1 (1A6) Mouse mAb
Datasheet
Catalog Number:
E2200627Amount:
100ulSource:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of CKMT1 and does not cross-react with related proteins.Entrez summary:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.UniPort summary Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.Immunogen:
Purified recombinant human CKMT1 protein fragments expressed in E.coli.Antibody type:
Monoclonal AntibodyIsotype:
IgG1Purification:
Affinity PurifiedCellular localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.Reactivity:
Human,MouseApplications:
WBMolecular Weight:
Calculated MW: 47 kDa; Observed MW: 47 kDaUniProt Number:
P12532Gene ID:
1159Gene symbol:
CKMT; CKMT1; UMTCK; CKMT1AAltername:
CKMT; CKMT1; UMTCK; CKMT1A
- Western blot analysis of CKMT1 in mouse Colon, 293 and A431 lysates using CKMT1 antibody.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.Clone Number:
1A6-C7-G10Gene Name:
CKMT1ARecommended Dilutions:
WB: 1/500-1/1000Swiss-Prot No.:
P12532Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Catalog Number
- Amount:100ul
- Price:255$
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