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hnRNP U (1B11) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200594

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of HNRNPU and does not cross-react with related proteins.

  • Entrez summary:

    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

  • UniPort summary Function:

    Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA.

  • Immunogen:

    Purified recombinant human hnRNP U protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm. Nucleus. Cell membrane. Membrane

  • Reactivity:

    Human

  • Applications:

    WB

  • Molecular Weight:

    Calculated MW: 91 kDa; Observed MW: 110 kDa

  • UniProt Number:

    Q00839

  • Gene ID:

    3192

  • Gene symbol:

    HNRPU; SAF-A; U21.1; hnRNP U

  • Altername:

    Heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.

  • Western blot analysis of hnRNP U in K562, Jurkat and Hela lysates using hnRNP U antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA.

  • Clone Number:

    1B11-H2-B7

  • Gene Name:

    HNRNPU

  • Recommended Dilutions:

    WB: 1/500-1/1000

  • Swiss-Prot No.:

    Q00839

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

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hnRNP U (1B11) Mouse mAb | EnoGene Biotech Co. Ltd