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TAB1 Antibody
Datasheet
Catalog Number:
E2200587Amount:
100ulSource:
MouseForm of Antibody:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerolSpecificity/Sensitivity:
This antibody detects endogenous levels TAB1(N-terminus) and does not cross-react with related proteins.Entrez summary:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reportedUniPort summary Function:
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesisImmunogen:
Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.Antibody type:
Monoclonal antibodyIsotype:
nullPurification:
Affinity purifiedCellular localization:
nullReactivity:
HApplications:
WBMolecular Weight:
55kDaUniProt Number:
Q15750Gene ID:
NM_006116Gene symbol:
3´-Tab1; MAP3K7IP1Altername:
3´-Tab1; MAP3K7IP1
- Western blot detection of TAB1(N-terminus) antibody in K562&Hela lysates using TAB1(N-terminus) antibody (1:1000 diluted). Predicted band size: 55KDa Observed band size: 55KDa.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsStorage/Stability:
Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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Catalog Number
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