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Syntenin 1 (3D9) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200585

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of SDCBP and does not cross-react with related proteins.

  • Entrez summary:

    The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.

  • UniPort summary Function:

    Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

  • Immunogen:

    Purified recombinant human Syntenin protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2b

  • Purification:

    Affinity Purified

  • Cellular localization:

    Nucleus. Cytoplasm. Mitochondrion. Note: Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.

  • Reactivity:

    Human

  • Applications:

    WB

  • Molecular Weight:

    Calculated MW: 32 kDa; Observed MW: 32 kDa

  • UniProt Number:

    O00560

  • Gene ID:

    6386

  • Gene symbol:

    ST1; SYCL; MDA-9; TACIP18

  • Altername:

    SDCBP; MDA9; SYCL; Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1

  • Western blot analysis of Syntenin in Hela lysates using Syntenin antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA).

  • Clone Number:

    3D9-G9-H4

  • Gene Name:

    SDCBP

  • Recommended Dilutions:

    WB: 1/500-1/1000

  • Swiss-Prot No.:

    O00560

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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Catalog Number

  • Amount:100ul
  • Price:255$

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Syntenin 1 (3D9) Mouse mAb | EnoGene Biotech Co. Ltd