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SAFB1 (2E8) Mouse mAb
Datasheet
Catalog Number:
E2200580Amount:
100ulSource:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of SAFB-1 and does not cross-react with related proteEntrez summary:
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a ´transcriptosome complex´ in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.UniPort summary Function:
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a ´transcriptosomal´ complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing By similarity. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter By similarity. Can inhibit cell proliferation.Immunogen:
Purified recombinant human SAFB1 protein fragments expressed in E.coli.Antibody type:
Monoclonal AntibodyIsotype:
IgG1Purification:
Affinity PurifiedCellular localization:
NucleusReactivity:
HumanApplications:
WB,ICC/IF,ChIPMolecular Weight:
Calculated MW: 103 kDa; Observed MW: 130 kDaUniProt Number:
Q15424Gene ID:
6294Gene symbol:
HAP; HET; SAFB1; SAF-B1Altername:
SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein
- Western blot analysis of SAFB1 in A431, MDA-MB-468, Breast cancer, ZR751 and MCF-7
lysates using SAFB1 antibody. 
- Immunocytochemistry analysis of SAFB1 (2E8) in HeLa using SAFB1 antibody.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.Clone Number:
2E8-E2-G6Gene Name:
SAFBRecommended Dilutions:
WB: 1/500-1/1000 IF: 1/50-1/200 ChIP: 1/20Swiss-Prot No.:
Q15424Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Catalog Number
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