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BARK1(ADRBK1,GRK2) Antibody
Datasheet
Catalog Number:
E2200551Amount:
100ulSource:
MouseForm of Antibody:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerolSpecificity/Sensitivity:
This antibody detects endogenous levels of ADRBK1(C-term.) and does not cross-react with related proteins.Entrez summary:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]UniPort summary Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.Immunogen:
Purified recombinant human ADRBK1(C-term.) protein fragments expressed in E.coli.Antibody type:
Monoclonal antibodyIsotype:
IgG1Purification:
Affinity purifiedCellular localization:
nullReactivity:
H.MApplications:
WBMolecular Weight:
80kDaUniProt Number:
P25098Gene ID:
NM_001619Gene symbol:
GRK2; BARK1; BETA-ARK1Altername:
beta-ARK-1 G-protein coupled receptor kinase 2
- Western blot detection of ADRBK1 in U937,Raw264.7&Ramos whole cell lysate(1:1000 diluted) Predicted band size:80KDa. Observed band size:80KDa.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsStorage/Stability:
Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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