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protein phosphatase 2A Antibody
Datasheet
Catalog Number:
E2200450Amount:
100ulSource:
MouseForm of Antibody:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerolSpecificity/Sensitivity:
This antibody detects endogenous levels PP2A-alpha (N-terminus) and does not cross-react with related proteins.Entrez summary:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.UniPort summary Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigenImmunogen:
Purified recombinant human PP2A-alpha (N-terminus) protein fragments expressed in E.coli.Antibody type:
Monoclonal antibodyIsotype:
IgG2aPurification:
Affinity purifiedCellular localization:
Cytoplasm. NucleusReactivity:
HApplications:
WB,ICCMolecular Weight:
35kDaUniProt Number:
P67775Gene ID:
NM_002715Gene symbol:
RP-C; PP2Ac; PP2CA; PP2CalphaAltername:
RP-C; PP2Ac; PP2Calpha;Protein Phosphatase 2 alpha
- Immunocytochemistry of HeLa cells using anti- PP2A-alpha (N-terminus) antibody diluted 1:50.
- Western blot detection of PP2A-alpha(N-terminus) antibody in MCF7 cell lysates using PP2A-alpha(N-terminus) antibody (1:1000 diluted). Predicted band size:35KDa. Observed band size:35KDa.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsStorage/Stability:
Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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Catalog Number
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