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ATP Citrate Lyase (3D9) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200359

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels ATP-Citrate Lyase and does not cross-react with related proteins.

  • Entrez summary:

    ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

  • UniPort summary Function:

    ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

  • Immunogen:

    Purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2a

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm

  • Reactivity:

    Human,Mouse,Monkey

  • Applications:

    WB,ICC/IF,FC

  • Molecular Weight:

    Calculated MW: 121 kDa; Observed MW: 121 kDa

  • UniProt Number:

    P53396

  • Gene ID:

    47

  • Gene symbol:

    ACL; ATPCL; CLATP

  • Altername:

    ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

  • Western blot analysis of ATPCitrate Lyase in 3T3, K562, COS7 and Hela lysates using ATPCitrate Lyase antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.

  • Clone Number:

    3D9-E9-H8

  • Gene Name:

    ACLY

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100

  • Swiss-Prot No.:

    P53396

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Western blot detection of ATP-Citrate Lyase antibody in K562&Hela cell lysates using ATP-Citrate Lyase antibody (1:1000 diluted). Predicted band size: 120KDa Observed size: 120KDa.

  • analysis of HeLa cells stained with ATP-Citrate Lyase (red, 1/100 dilution), goat anti-mouse IgG. Black line histogram represents the isotype control, normal

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Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

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ATP Citrate Lyase (3D9) Mouse mAb | EnoGene Biotech Co. Ltd