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Hsp70 1A (2D4) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200303

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels Hsp70(N-terminus) and does not cross-react with related proteins.

  • Entrez summary:

    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

  • UniPort summary Function:

    In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell

  • Immunogen:

    Purified recombinant human Hsp70(N-terminus) protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm

  • Reactivity:

    Human

  • Applications:

    WB,ICC/IF

  • Molecular Weight:

    Calculated MW: 70 kDa; Observed MW: 70 kDa

  • UniProt Number:

    P08107

  • Gene ID:

    3303

  • Gene symbol:

    HSP72; HSPA1; HSP70I; HSPA1B; HSP70-1; HSP70-1A

  • Altername:

    HSP72; HSPA1; HSP70I; HSPA1B; HSP70-1; HSP70-1A.

  • Western blot analysis of Hsp70(Nterminus) in Hela and HepG2 lysates using Hsp70(Nterminus) antibody.

  • Immunocytochemistry analysis of Hsp70 1A (2D4) in Hela using Hsp70 (Nterminus) antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

  • Clone Number:

    2D4-F7-C11

  • Gene Name:

    HSPA1A

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200

  • Swiss-Prot No.:

    P0DMV8

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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Catalog Number

  • Amount:100ul
  • Price:255$

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