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Pyruvate Dehydrogenase E1 alpha (3H2) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200270

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels Pyruvate Dehydrogenase and does not cross-react with related proteins.

  • Entrez summary:

    The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • UniPort summary Function:

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

  • Immunogen:

    Purified recombinant human Pyruvate Dehydrogenase protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Mitochondrion matrix

  • Reactivity:

    Human,Mouse

  • Applications:

    WB,ICC/IF

  • Molecular Weight:

    Calculated MW: 43 kDa; Observed MW: 43 kDa

  • UniProt Number:

    P08559

  • Gene ID:

    5160

  • Gene symbol:

    PDHA; PHE1A; PDHCE1A

  • Altername:

    mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 component subunit alpha; Pyruvate dehydrogenase E1 component subunit alpha; somatic form; mitochondrial; somatic form.

  • Western blot analysis of pyruvate dehydrogenase (lipoamide) alpha 1 in 293, 1299, mEsc and Tc1 lysates using pyruvate dehydrogenase (lipoamide) alpha 1 antibody.

  • Immunocytochemistry analysis of Pyruvate Dehydrogenase E1 alpha (3H2) in HeLa using pyruvate dehydrogenase (lipoamide) alpha 1 antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Catalyzes the removal of CO2 from pyruvate. Mutations in the α subunits of pyruvate dehydrogenase (E1) lead to congenital defects that are usually associated with lactic acidosis, neurodegeneration and early death.

  • Clone Number:

    3H2-F8-B5

  • Gene Name:

    PDHA1

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200

  • Swiss-Prot No.:

    P08559

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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Catalog Number

  • Amount:100ul
  • Price:255$

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Pyruvate Dehydrogenase E1 alpha (3H2) Mouse mAb | EnoGene Biotech Co. Ltd