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PPP4C (2F11) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200228

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels Protein Phosphatase 4C and does not cross-react with related proteins.

  • Entrez summary:

    Protein phosphatase 4C may be involved in microtubule organization. It binds 1 iron ion and 1 manganese ion per subunit. PP4 consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily.

  • UniPort summary Function:

    Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity)

  • Immunogen:

    Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2a

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm. Nucleus

  • Reactivity:

    Human

  • Applications:

    WB,IHC-F,IHC-P,ICC/IF

  • Molecular Weight:

    Calculated MW: 35 kDa; Observed MW: 35 kDa

  • UniProt Number:

    P60510

  • Gene ID:

    5531

  • Gene symbol:

    PP4; PPX; PP4C; PPH3; PPP4

  • Altername:

    PP4; PPX; PP4C; PPH3; PPP4

  • Western blot analysis of Protein Phosphatase 4C in Hela and Jurkat lysates using Protein Phosphatase 4C antibody.

  • Immunocytochemistry analysis of PPP4C in HeLa cells using PPP4C antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

  • Clone Number:

    2F11-D10-G4

  • Gene Name:

    PPP4C

  • Recommended Dilutions:

    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

  • Swiss-Prot No.:

    P60510

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • human breast cancer using anti-Protein Phosphatase 4C diluted

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Catalog Number

  • Amount:100ul
  • Price:255$

Add to Cart

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PPP4C (2F11) Mouse mAb | EnoGene Biotech Co. Ltd