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Dynactin Subunit 1 (3D5) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200090

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of Dynactin 1(N-terminus),and does not cross-react with related proteins.

  • Entrez summary:

    This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).[provided by RefSeq, Oct 2008]

  • UniPort summary Function:

    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.

  • Immunogen:

    Purified recombinant Dynactin 1 protein fragments expressed in E.coli

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2b

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm

  • Reactivity:

    Human

  • Applications:

    WB,IP

  • Molecular Weight:

    Calculated MW: 142 kDa; Observed MW: 142 kDa

  • UniProt Number:

    Q14203

  • Gene ID:

    1639

  • Gene symbol:

    P135; DP-150; DAP-150

  • Altername:

    P135; DP-150; DAP-150

  • Western blot analysis of Dynactin 1 in K562, MCF-7, 293T and Hela lysates using Dynactin 1 antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Loading Control Antibody

  • Background:

    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.

  • Clone Number:

    3D5-C6-D5

  • Gene Name:

    DCTN1

  • Recommended Dilutions:

    WB: 1/1000 IP: 1/20

  • Swiss-Prot No.:

    Q14203

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Immunoprecipitation analysis of Hela cell lysates using DCTN1 antibody.

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Catalog Number

  • Amount:100ul
  • Price:255$

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Dynactin Subunit 1 (3D5) Mouse mAb | EnoGene Biotech Co. Ltd