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JMJD6 (3G5) Mouse mAb
Datasheet   

  • Catalog Number:

    E2200058

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of JMJD6(N-terminus) and does not cross-react with related proteins.

  • Entrez summary:

    This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

  • UniPort summary Function:

    Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at ´Arg-2´ (H3R2me) and histone H4 at ´Arg-3´ (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

  • Immunogen:

    Purified recombinant human JMJD6(N-terminus) fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG1

  • Purification:

    Affinity Purified

  • Cellular localization:

    Nucleus

  • Reactivity:

    Human

  • Applications:

    WB,ICC/IF

  • Molecular Weight:

    Calculated MW: 46 kDa; Observed MW: 62 kDa

  • UniProt Number:

    Q6NYC1

  • Gene ID:

    23210

  • Gene symbol:

    PSR; PTDSR; PTDSR1

  • Altername:

    JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox

  • Western blot analysis of JMJD6(Nterminus) in Hela and HL-60 lysates using JMJD6(Nterminus) antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Clone Number:

    3G5-G5-H8

  • Gene Name:

    JMJD6

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200

  • Swiss-Prot No.:

    Q6NYC1

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

  • Western blot detection of JMJD6(N-terminus) antibody in Hela&HL-60 lysates using JMJD6(N-terminus) antibody (1:1000 diluted). Predicted band size: 46KDa Observed band size: 62KDa.

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Catalog Number

  • Amount:100ul
  • Price:255$

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JMJD6 (3G5) Mouse mAb | EnoGene Biotech Co. Ltd