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KDM5C (2E4) Mouse mAb
Datasheet
Catalog Number:
E2200054Amount:
100ulStorage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.Source:
MouseForm of Antibody:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.Specificity/Sensitivity:
This antibody detects endogenous levels of KDM5C and does not corss-react with related proteinsEntrez summary:
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.UniPort summary Function:
Histone demethylase that specifically demethylates ´Lys-4´ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ´Lys-9´, H3 ´Lys-27´, H3 ´Lys-36´, H3 ´Lys-79´ or H4 ´Lys-20´. Demethylates trimethylated and dimethylated but not monomethylated H3 ´Lys-4´. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.Immunogen:
Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coliAntibody type:
Monoclonal AntibodyIsotype:
IgG2aPurification:
Affinity PurifiedCellular localization:
NucleusReactivity:
HumanApplications:
WB,ICC/IFMolecular Weight:
Calculated MW: 176 kDa; Observed MW: 220 kDaUniProt Number:
P412298Gene ID:
8242Gene symbol:
MRXJ; SMCX; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272EAltername:
MRXJ; SMCX; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272E
- Western blot analysis of KDM5C / Jarid1C / SMCX in Hela and 293 lysates using KDM5C / Jarid1C / SMCX antibody.
Price:
255$Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem CellsProduct Type:
Primary AntibodyBackground:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.Clone Number:
2E4-E1-G8Gene Name:
KDM5CRecommended Dilutions:
WB: 1/500-1/1000 IF: 1/50-1/200Swiss-Prot No.:
P41229
Western blot detection of KDM5C(C-terminus) antibody in Hela&293 cell lysates using KDM5C(C-terminus) antibody (1:1000 diluted). Predicted band size: 176KDa Observed band size: 220KDa.
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