Other Names IP3 receptor isoform 1, IP3R, ITPR1, Inositol 1,4,5-trisphosphate receptor type 1, InsP3R1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5- trisphosphate receptor
All Sites Human: Ser1598; Mouse: Ser1588; Rat: Ser1589
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Inositol 1,4,5-trisphosphate R1 around the phosphorylation site of serine 1598/1588 (R-D-SP-V-L).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity Inositol 1,4,5-trisphosphate R1 (Phospho-Ser1598/1588) antibody detects endogenous levels of Inositol 1,4,5-trisphosphate R1 only when phosphorylated at serine 1598/1588.
ReferencesMitsuharu Hattori, J. Biol. Chem., Mar 2004; 279: 11967 - 11975.
MA Dent, Development, Mar 1996; 122: 1029.
Henk Sipma, J. Biol. Chem., Apr 1999; 274: 12157.