Other Names GRB10 adaptor protein, GRBIR, Growth factor receptor-bound protein 10, Insulin receptor binding protein GRB-IR, KIAA0207
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human GRB10 around the phosphorylation site of tyrosine 67 (S-L-YP-S-A).
Purification The antibody was affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity GRB10 (Phospho-Tyr67) antibody detects endogenous levels of GRB10 only when phosphorylated at tyrosine 67.
ReferencesLiu F., Proc. Natl. Acad. Sci. U.S.A. 92:10287-10291(1995).
Angrist M., Oncogene 17:3065-3070(1998).
Nagase T., DNA Res. 3:321-329(1996).
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells