Other Names p53-binding protein 1; P531; TP53B; TP53BP1; TRP53BP1; Tumor suppressor p53-binding protein 1
All Sites Human: Ser6; Mouse: Ser6; Rat: Ser11
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human 53BP1 around the phosphorylation site of serine 6 (T-G-SP-Q-L).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity 53BP1 (Phospho-Ser6) antibody detects endogenous levels of 53BP1 only when phosphorylated at serine 6.
ReferencesIwabuchi K., J. Biol. Chem. 273:26061-26068(1998).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Iwabuchi K., Proc. Natl. Acad. Sci. U.S.A. 91:6098-6102(1994).
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells