Other Names 1-phosphatidylinositol-4, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3, 5-bisphosphate phosphodiesterase beta 3, EC 3.1.4.11, PLC-beta-3, PLC-beta3, Phospholipase C-beta-3
All Sites Human: Ser537; Mouse: Ser537; Rat: Ser535
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PLC β3 around the phosphorylation site of serine 537 (Q-K-SP-L-G).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity PLC β3 (Phospho-Ser537) antibody detects endogenous levels of PLC β3 only when phosphorylated at serine 537.
ReferencesMazuruk K., Biochem. Biophys. Res. Commun. 212:190-195(1995).
Lagercrantz J., Genomics 26:467-472(1995).
Carozzi A.J., Eur. J. Biochem. 210:521-529(1992).
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells